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pentobarbital will minimize the extent or effect of dienogest/estradiol valerate by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Females mustn't opt for estradiol valerate/dienogest as their contraceptive when using powerful CYP3A4 inducers as a result of probable lessen in contraceptive efficacy.pentobarbital will decrea